Osteoinductive peptide-functionalized nanofibers with highly ordered structure as biomimetic scaffolds for bone tissue engineering

Osteoinductive peptide-functionalized nanofibers with highly ordered structure as biomimetic scaffolds for bone tissue engineering

The construction of functional biomimetic scaffolds that recapitulate the topographical and biochemical features of bone tissue extracellular matrix is now of topical interest in bone tissue engineering. In this study, a novel surface-functionalized electrospun polycaprolactone (PCL) nanofiber scaffold with highly ordered structure was developed to simulate the critical features of native bone ...

Biodegradable nanofibers-reinforced microfibrous composite scaffolds for bone tissue engineering.

Native bone extracellular matrix (ECM) is a complex hierarchical fibrous composite structure, resulting from the assembling of collagen fibrils at several length scales, ranging from the macro to the nanoscale. The combination of nanofibers within microfibers after conventional reinforcement methodologies seems to be a feasible solution to the rational design of highly functional synthetic ECM ...

Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering

Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...

Biomimetic Calcium Phosphate-Polycarbonate Composite Scaffolds for Bone Tissue Engineering

Shuang S Chen and Joachim Kohn New Jersey Center for Biomaterials, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, United States. Statement of Purpose: Large bone defects resulting from trauma, tumor resection, congenital abnormalities or reconstructive surgery are challenging clinical problems that are usually treated with autografts and allografts. However, donor sit...

Poly(lactic acid) (PLA) Nanofibers for Bone Tissue Engineering